Targeting eosinophils in allergy, inflammation and beyond

被引：411

作者：

Fulkerson, Patricia C. ^{[1
]}

Rothenberg, Marc E. ^{[1
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Div Allergy & Immunol, Dept Pediat, Cincinnati, OH 45229 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2013年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

HISTAMINE H-4 RECEPTOR; MAJOR BASIC-PROTEIN; ANTI-IL-5 MEPOLIZUMAB THERAPY; GAMMA-SECRETASE-INHIBITOR; INTERCELLULAR-ADHESION MOLECULE-1; PROSTAGLANDIN D-2 RECEPTOR; MATURE HUMAN EOSINOPHILS; PROGRAMMED CELL-DEATH; E ANTIBODY OMALIZUMAB; AIRWAY INFLAMMATION;

D O I：

10.1038/nrd3838

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Eosinophils can regulate local immune and inflammatory responses, and their accumulation in the blood and tissue is associated with several inflammatory and infectious diseases. Thus, therapies that target eosinophils may help control diverse diseases, including atopic disorders such as asthma and allergy, as well as diseases that are not primarily associated with eosinophils, such as autoimnnunity and malignancy. Eosinophil-targeted therapeutic agents that are aimed at blocking specific steps involved in eosinophil development, migration and activation have recently entered clinical testing and have produced encouraging results and insights into the role of eosinophils. In this Review, we describe recent advances in the development of first-generation eosinophil-targeted therapies and highlight strategies for using personalized medicine to treat eosinophilic disorders.

引用

页码：117 / 129

页数：13

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