The regulation and pharmacology of endothelial nitric oxide synthase

被引：294

作者：

Dudzinski, DM

Igarashi, J

Greif, D

Michel, T

机构：

[1] Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Kagawa Univ, Dept Cardiovasc Physiol, Kagawa, Japan

[4] Stanford Univ, Sch Med, Div Cardiovasc Med, Falk Cardiovasc Res Ctr, Stanford, CA 94305 USA

[5] Vet Affairs Boston Healthcare Syst, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2006年 / 46卷

关键词：

eNOS; caveolae; vascular signaling; sphingosine l-phosphate; VEGF; cyclic GMP; S-nitrosylation; oxidative stress;

D O I：

10.1146/annurev.pharmtox.44.101802.121844

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates significant and diverse signaling functions in nearly every organ system in the body. The endothelial isoform of nitric oxide synthase (eNOS) is a key source of NO found in the cardiovascular system. This review summarizes the pharmacology of NO and the cellular regulation of endothelial NOS (eNOS). The molecular intricacies of the chemistry of NO and the enzymology of NOSs are discussed, followed by a review of the biological activities of NO. This information is then used to develop a more global picture of the pharmacological control of NO synthesis by NOSs in both physiologic conditions and pathophysiologic states.

引用

收藏

页码：235 / 276

页数：44

相关论文

共 224 条

[61] Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate [J].

Goetzl, EJ ;

An, SZ .

FASEB JOURNAL, 1998, 12 (15) :1589-1598

[62] Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease [J].

Gokce, N ;

Keaney, JF ;

Frei, B ;

Holbrook, M ;

Olesiak, M ;

Zachariah, BJ ;

Leeuwenburgh, C ;

Heinecke, JW ;

Vita, JA .

CIRCULATION, 1999, 99 (25) :3234-3240

[63] HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI-dependent manner [J].

Gong, M ;

Wilson, M ;

Kelly, T ;

Su, W ;

Dressman, J ;

Kincer, J ;

Matveev, SV ;

Guo, L ;

Guerin, T ;

Li, XA ;

Zhu, WF ;

Uittenbogaard, A ;

Smart, EJ .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (10) :1579-1587

[64] Subcellular targeting and agonist-induced site-specific phosphorylation of endothelial nitric-oxide synthase [J].

Gonzalez, E ;

Kou, R ;

Lin, AJ ;

Golan, DE ;

Michel, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (42) :39554-39560

[65] Effects of nitric oxide and nitric oxide-derived species on prostaglandin endoperoxide synthase and prostaglandin biosynthesis [J].

Goodwin, DC ;

Landino, LM ;

Marnett, LJ .

FASEB JOURNAL, 1999, 13 (10) :1121-1136

[66] Calmodulin phosphorylation and modulation of endothelial nitric oxide synthase catalysis [J].

Greif, DM ;

Sacks, DB ;

Michel, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (05) :1165-1170

[67] Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition [J].

Gudi, S ;

Nolan, JP ;

Frangos, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) :2515-2519

[68] The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women [J].

Guetta, V ;

Quyyumi, AA ;

Prasad, A ;

Panza, JA ;

Waclawiw, M ;

Cannon, RO .

CIRCULATION, 1997, 96 (09) :2795-2801

[69] Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation [J].

Harris, MB ;

Ju, H ;

Venema, VJ ;

Liang, HY ;

Zou, R ;

Michell, BJ ;

Chen, ZP ;

Kemp, BE ;

Venema, RC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (19) :16587-16591

[70] Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through Flk-1/KDR activation of c-Src [J].

He, H ;

Venema, VJ ;

Guo, XL ;

Venema, RC ;

Marrero, MB ;

Caldwell, RB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (35) :25130-25135

← 2 3 4 5 6 7 8 9 10 11 →