The regulation and pharmacology of endothelial nitric oxide synthase

被引：294

作者：

Dudzinski, DM

Igarashi, J

Greif, D

Michel, T

机构：

[1] Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Kagawa Univ, Dept Cardiovasc Physiol, Kagawa, Japan

[4] Stanford Univ, Sch Med, Div Cardiovasc Med, Falk Cardiovasc Res Ctr, Stanford, CA 94305 USA

[5] Vet Affairs Boston Healthcare Syst, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2006年 / 46卷

关键词：

eNOS; caveolae; vascular signaling; sphingosine l-phosphate; VEGF; cyclic GMP; S-nitrosylation; oxidative stress;

D O I：

10.1146/annurev.pharmtox.44.101802.121844

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates significant and diverse signaling functions in nearly every organ system in the body. The endothelial isoform of nitric oxide synthase (eNOS) is a key source of NO found in the cardiovascular system. This review summarizes the pharmacology of NO and the cellular regulation of endothelial NOS (eNOS). The molecular intricacies of the chemistry of NO and the enzymology of NOSs are discussed, followed by a review of the biological activities of NO. This information is then used to develop a more global picture of the pharmacological control of NO synthesis by NOSs in both physiologic conditions and pathophysiologic states.

引用

收藏

页码：235 / 276

页数：44

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