Interleukin-18/-607 gene polymorphism in allergic rhinitis

被引：25

作者：

Lee, Heung-Man ^{[1
]}

Park, Sook Ah ^{[1
]}

Chung, Seung-Won ^{[1
]}

Woo, Jeong Soo ^{[1
]}

Chae, Sung Won ^{[1
]}

Lee, Sang Hag ^{[1
]}

Kang, Hee Joon ^{[1
]}

Hwang, Soon Jae ^{[1
]}

机构：

[1] Korea Univ, Coll Med, Med Sci Res Ctr, Commun Disorder Inst,Dept Otorhinolaryngol Head &, Seoul 136701, South Korea

来源：

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | 2006年 / 70卷 / 06期

关键词：

allergic rhinitis; IL-18 gene polymorphism;

D O I：

10.1016/j.ijporl.2005.11.006

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-gamma-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. Study design: Prospective study. Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P < 0.05). Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1085 / 1088

页数：4

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