Dietary sphingolipids in colorectal cancer prevention

被引:62
作者
Berra, B
Colombo, I
Sottocornola, E
Giacosa, A [1 ]
机构
[1] Natl Inst Canc Res, Dept Gastroenterol & Nutr, Genoa, Italy
[2] Univ Milan, Sch Pharm, Inst Gen Physiol & Biol Chem, Milan, Italy
关键词
colorectal cancer; prevention; sphingolipids; cell signalling; antiproliferative pathways; apoptosis;
D O I
10.1097/00008469-200204000-00013
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Sphingolipids are widespread membrane components that are found in all eukaryotic cells. They consist of a long chain sphingoid-base, usually sphingosine, which is acylated at the 2-amino position, forming a ceramide. All together, sphingolipids may represent the most structurally diverse category of lipids in nature. There is no known nutritional requirement for sphingolipids. Nonetheless, studies with experimental animals have shown that consumption of sphingolipids inhibits colon carcinogenesis, reduces serum low-density lipoprotein cholesterol and elevates high-density lipoproteins, which suggest that they are 'functional' components of food. In animal models (CF1 mice) sphingomyelin supplementation reduces the number of aberrant colonic crypt foci by approximately 70% and, with longer feeding, reduces the number of colonic adenocarcinomas. A possible mechanism of action of sphingolipids in suppressing colon carcinogenesis is that exogenously supplied sphingolipids bypass a sphingolipid signalling defect that is important in cancer (for example, a loss of cellular sphingomyelin turnover to produce ceramide and sphingosine). Indirect evidence suggests that sphingolipids can inhibit colon cancer in humans: sphingosine and ceramide induce apoptosis in a human adenocarcinoma cell line and feeding sphingolipids to Min mice reduces the number of colon tumours. (C) 2002 Lippincott Williams Wilkins.
引用
收藏
页码:193 / 197
页数:5
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