Protection of immunosuppressed mice from lethal Candida infection by oral administration of a Kampo medicine, Hochu-ekki-to

被引：20

作者：

Abe, S

Tansho, S

Ishibashi, H

Akagawa, G

Komatsu, Y

Yamaguchi, H

机构：

[1] Teikyo Univ, Sch Med, Dept Microbiol & Immunol, Itabashi Ku, Tokyo 1738605, Japan

[2] Tsumura & Co, Dept Kampo Pharmacol, Cent Res Inst, Ami, Ibaraki 3001155, Japan

[3] Teikyo Univ, Res Ctr Med Mycol, Tokyo 1920352, Japan

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 1999年 / 21卷 / 02期

关键词：

D O I：

10.3109/08923979909052766

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The protective effect of a Kampo medicine, Hochu-ekki-to (TJ-41) on experimental candidiasis in immunosuppressed mice was investigated. ICR mice were immunosuppressed by injection of prednisolone or cyclophosphamide, given TJ-41 orally and challenged intravenously with Candida albicans (day 0). Treatments with a daily dose of 1g/kg/day of TJ-41 for 8 days from day-4 or for 4 days from day 0 significantly prolonged the life span of the Candida-infected mice pretreated with prednisolone. The latter treatment appeared to inhibit the colonization of Candida in kidneys of the infected mice. These results suggest that Hochu-ekki-to can be used as a therapeutic agent against candidiasis in patients with glucocorticoid-induced immunosuppression.

引用

页码：331 / 342

页数：12

共 19 条

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[2]

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[3]

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