A new rearranged cholestane glycoside from Ornithogalum saundersiae bulbs exhibiting potent cytostatic activities on leukemia HL-60 and MOLT-4 cells

被引:23
作者
Mimaki, Y [1 ]
Kuroda, M [1 ]
Kameyama, A [1 ]
Sashida, Y [1 ]
Hirano, T [1 ]
Oka, K [1 ]
Dobashi, A [1 ]
机构
[1] TOHO UNIV,SCH PHARMACEUT SCI,FUNABASHI,CHIBA 274,JAPAN
关键词
D O I
10.1016/S0960-894X(96)00486-6
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A new rearranged cholestane glycoside (1) was isolated from Ornithogalum saundersiae bulbs by monitoring the cytostatic activity on leukemia HL-60 cells. Compound 1 was exceptionally cytostatic against HL-60 and MOLT-4 cells, which was revealed to be mediated partially through induction of apoptosis. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:2635 / 2638
页数:4
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