A new rearranged cholestane glycoside from Ornithogalum saundersiae bulbs exhibiting potent cytostatic activities on leukemia HL-60 and MOLT-4 cells

被引：23

作者：

Mimaki, Y ^{[1
]}

Kuroda, M ^{[1
]}

Kameyama, A ^{[1
]}

Sashida, Y ^{[1
]}

Hirano, T ^{[1
]}

Oka, K ^{[1
]}

Dobashi, A ^{[1
]}

机构：

[1] TOHO UNIV,SCH PHARMACEUT SCI,FUNABASHI,CHIBA 274,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(96)00486-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new rearranged cholestane glycoside (1) was isolated from Ornithogalum saundersiae bulbs by monitoring the cytostatic activity on leukemia HL-60 cells. Compound 1 was exceptionally cytostatic against HL-60 and MOLT-4 cells, which was revealed to be mediated partially through induction of apoptosis. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2635 / 2638

页数：4

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