The 1200 Patients Project: Creating a New Medical Model System for Clinical Implementation of Pharmacogenomics

被引：141

作者：

O'Donnell, P. H. ^{[1
,2
,3
]}

Bush, A. ^{[3
]}

Spitz, J. ^{[3
]}

Danahey, K. ^{[4
]}

Saner, D. ^{[4
]}

Das, S. ^{[2
,5
]}

Cox, N. J. ^{[1
,2
,3
,5
]}

Ratain, M. J. ^{[1
,2
,3
]}

机构：

[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[2] Univ Chicago, Comm Clin Pharmacol & Pharmacogenom, Chicago, IL 60637 USA

[3] Univ Chicago, Ctr Personalized Therapeut, Chicago, IL 60637 USA

[4] Univ Chicago, Ctr Res Informat, Chicago, IL 60637 USA

[5] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 92卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/clpt.2012.117

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The paradigm of individualized drug therapy based on genetics is an ideal that is now potentially possible. However, translation of pharmacogenomics into practice has encountered barriers such as limited availability and the high cost of genetic testing, the delays involved, disagreements about interpretation of results, and even lack of understanding about pharmacogenomics in general. We describe our institutional pharmacogenomics-implementation project, "The 1200 Patients Project," a model designed to overcome these barriers and facilitate the availability of pharmacogenomic information for personalized prescribing.

引用

页码：446 / 449

页数：4

共 5 条

[1]

Pharmacogenomics: "Noninferiority" Is Sufficient for Initial Implementation [J].