Low expression of microRNA-204 (miR-204) is associated with poor clinical outcome of acute myeloid leukemia (AML) patients

被引：50

作者：

Butrym, Aleksandra ^{[1
,2
]}

Rybka, Justyna ^{[1
]}

Baczynska, Dagmara ^{[3
]}

Tukiendorf, Andrzej ^{[4
]}

Kuliczkowski, Kazimierz ^{[1
]}

Mazur, Grzegorz ^{[5
]}

机构：

[1] Wroclaw Med Univ, Dept Hematol Blood Neoplasms & Bone Marrow Transp, Pasteur 4 Str, PL-50367 Wroclaw, Poland

[2] Wroclaw Med Univ, Dept Physiol, PL-50367 Wroclaw, Poland

[3] Wroclaw Med Univ, Dept Forens Med, Mol Tech Unit, PL-50367 Wroclaw, Poland

[4] Canc Ctr Inst Oncol, Dept Epidemiol, Gliwice, Poland

[5] Wroclaw Med Univ, Dept Internal & Occupat Dis & Hypertens, PL-50367 Wroclaw, Poland

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2015年 / 34卷

关键词：

miR-204; Acute myeloid leukemia; Expression; Survival; Prognosis; CANCER; MIGRATION;

D O I：

10.1186/s13046-015-0184-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Background: Acute myeloid leukemia (AML) is a heterogeneous neoplasm of the bone marrow with poor prognosis. In clinical practice new prognostic factors are still needed. MicroRNAs (miRs), small endogenous noncoding RNAs, play an essential role in the development and progression of acute leukemia. The aim of the study was to evaluate miR-204 expression in patients with AML at diagnosis and after induction chemotherapy, in comparison to healthy controls. We also investigated, if miR-204 expression correlates with clinical features of AML patients. Methods: miR-204 expression has been analyzed using RT-PCR in 95 bone marrow specimens from newly diagnosed AML patients in comparison to 20 healthy subject. Results: We showed down-regulated miR-204 expression in AML patients, which was associated with shorter patients' survival. Higher expression of miR-204 in patients after induction therapy was correlated with complete remission achieving. Conclusions: We showed low miR-204 expression in AML and found it to be an independent prognostic factor in this patient population.

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