Prevention of Relapse With Maintenance Electroconvulsive Therapy in Elderly Patients With Major Depressive Episode

被引：13

作者：

Rapinesi, Chiara ^{[1
,2
]}

Kotzalidis, Georgios Demetrios ^{[1
]}

Serata, Daniele ^{[1
,2
]}

Del Casale, Antonio ^{[1
]}

Scatena, Paola ^{[1
,2
]}

Mazzarini, Lorenzo ^{[1
,2
]}

Caccia, Federica ^{[1
]}

Brugnoli, Roberto ^{[1
]}

Carbonetti, Paolo ^{[2
]}

Fensore, Claudio ^{[2
]}

Girardi, Paolo ^{[1
,2
]}

机构：

[1] Univ Roma La Sapienza, St Andrea Hosp, Sch Med & Psychol, NESMOS Dept Neurosci Mental Hlth & Sensory Organs, I-00189 Rome, Italy

[2] Suore Hosp Sacred Heart Jesus, Dept Neuropsychiat, Viterbo, Italy

来源：

JOURNAL OF ECT | 2013年 / 29卷 / 01期

关键词：

electroconvulsive therapy; maintenance; aging; major depressive episode; ECT; EFFICACY; DISORDER; RECOVERY; SAFETY;

D O I：

10.1097/YCT.0b013e31826d369a

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

Objectives: To evaluate the effectiveness and safety of maintenance electroconvulsive therapy (mECT) in elderly patients with treatment-resistant Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition major depressive episode. Methods: Seven elderly patients with treatment-resistant major depressive episode were treated with a complete ECT cycle. Thereafter, they received one monthly ECT session as maintenance for 1 year. Response to treatment was defined as at least a 50% drop from baseline on the Hamilton Depression Rating Scale (HamD) and remission as not meeting criteria for major depression, a HamD score of 7 or less, and Clinical Global Impressions-Severity of Illness score of 1. We compared their response with the response of 7 elderly patients with treatment-resistant major depression who were treated with a full cycle of ECT but did not receive mECT (non-mECT). We compared the 2 groups for the number of relapses or recurrences of major depressive episodes after remission was achieved; a relapse or a recurrence occurred when HamD scores were 14 or higher, or when Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision major depressive episode criteria were met, or when Clinical Global Impressions-Severity of Illness score was 3 or higher and increased by at least 2 points from response/remission. Results: The mECT group (4 women and 3 men; mean age, 73 years) had significantly less mean relapses/recurrences (0 vs 1.57) and hospitalizations (0 vs 1) and received less drug treatment than the nonMECT group (similar for age and sex composition) during the 12-month follow-up period. All patients with mECT improved during treatment and did not relapse. Conclusions: Maintenance ECT protected elderly patients from recurrent depressive episodes from relapsing/recurring more than standard ECT.

引用

页码：61 / 64

页数：4

共 23 条

[1]

Abrams R., 2002, Electroconvulsive Therapy, V4th, P17

[2]

American Psychiatric Association Committee on Electroconvulsive Therapy, 2001, The practice of electroconvulsive therapy: recommendations for treatment, training, and privileging, V2nd

[3]

Selegiline transdermal system in the prevention of relapse of major depressive disorder - A 52-week, double-blind, placebo-substitution, parallel-group clinical trial [J].