Characterization of the human laminin β2 chain locus (LAMB2):: linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS)

被引：5

作者：

Durkin, ME

Jäger, AC

Khurana, TS

Nielsen, FC

Albrechtsen, R

Wewer, UM

机构：

[1] Univ Copenhagen, Inst Mol Pathol, DK-2100 Copenhagen, Denmark

[2] Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark

[3] Glostrup Cty Hosp, Dept Clin Biochem, Glostrup, Denmark

来源：

CYTOGENETICS AND CELL GENETICS | 1999年 / 84卷 / 3-4期

关键词：

D O I：

10.1159/000015249

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The laminin beta 2 chain is an important constituent of certain kidney and muscle basement membranes. We have generated a detailed physical map of a 110-kb genomic DNA segment surrounding the human laminin beta 2 chain gene (LAMB2) on chromosome 3p21.3 --> p21.2, a region paralogous with the chromosome 7q22 --> q31 region that contains the laminin beta 1 chain gene locus (LAMB1). Several CpG islands and a novel polymorphic microsatellite marker (D3S4594) were identified. The 3' end of LAMB2 lies 16 kb from the 5' end of the glutaminyl tRNA synthetase gene (QARS), About 20 kb upstream of LAMB2 we found a gene encoding a transcribed, non-processed LAMB2-like pseudogene (LAMB2L). The sequence of 1.75 kb of genomic DNA at the 3' end of LAMB2L was similar to exons 8-12 of the laminin beta 2 chain gene. The LAMB2L-LAMB2-QARS cluster lies telomeric to the gene encoding the laminin-binding protein dystroglycan (DAG1).

引用

页码：173 / 178

页数：6

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