Rationally designed chemical modulators convert a bacterial channel protein into a pH-sensory valve

被引：53

作者：

Kocer, Armagan

Walko, Martin

Bulten, Erna

Halza, Erik

Feringa, Ben L.

Meijberg, Wim

机构：

[1] Univ Groningen, Stratingh Inst & Mat Sci Ctr, Dept Organ & Mol Inorgan Chem, NL-9747 AG Groningen, Netherlands

[2] Univ Groningen, BIOMaDe Technol Fdn, NL-9747 AG Groningen, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 19期

关键词：

biosensors; drug delivery; membrane proteins; protein modifications; protonation;

D O I：

10.1002/anie.200503403

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Open channels: Chemical modulators are developed to convert a naturally occurring channel protein into a pH-actuated nanovalve. The pH interval, sensitivity, and activation of the valve by channel opening are tunable through the design of the modulators. The valve is useful for releasing or mixing the contents of liposomes at a desired location, time, and dosage, for example, in micro/nanosensory and delivery devices (see picture). (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3126 / 3130

页数：5

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