Surface Functionalization of Hydrophobic Nanocrystals with One Particle per Micelle for Bioapplications

被引：43

作者：

Deng, Mingliang ^{[1
]}

Nina Tu ^{[1
]}

Bai, Feng ^{[2
]}

Wang, Leyu ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Sch Sci, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China

[2] Henan Univ, Minist Educ, Key Lab Special Funct Mat, Kaifeng 475004, Peoples R China

来源：

CHEMISTRY OF MATERIALS | 2012年 / 24卷 / 13期

基金：

中国国家自然科学基金;

关键词：

hydrophobic nanocrystals; surface functionalization; cell imaging; MESOPOROUS SILICA SPHERES; IRON-OXIDE NANOPARTICLES; QUANTUM DOTS; PHOSPHATE NANOCRYSTALS; PHOSPHOLIPID MICELLES; COLLOIDAL SPHERES; DELIVERY; LUMINESCENT; CAPSULES; NANORODS;

D O I：

10.1021/cm301285g

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

A facile and general strategy was successfully developed for the surface modification of kinds of hydrophobic inorganic nanomaterials with various chemical compositions, shapes, and sizes. Via this ultrasonication assistant encapsulation technology, these hydrophobic inorganic nanocrystals were successfully encapsulated into the carboxylated phospholipids and polymers micelles with one particle per micelle. The surface modified nanocrystals were characterized by transmission electron microscopy (TEM), Fourier-transform infrared (FTIR), and thermogravimetric analysis (TGA). After encapsulation, the particle size, shape, and optical and magnetic properties were effectively retained. These functionalized nanocrystals are highly water-stable and biocompatible. After being bioconjugated with the antibodies, the functionalized quantum dots (QDs) have been successfully used as biolabels for targeted cell fluorescence imaging.

引用

页码：2592 / 2597

页数：6

共 48 条

[1]

Polymeric Multilayers that Contain Silver Nanoparticles can be Stamped onto Biological Tissues to Provide Antibacterial Activity [J].