Stop Press: Eosinophils Drafted to Join the Th17 Team

被引:16
作者
Keely, Simon [1 ,2 ]
Foster, Paul S. [1 ,2 ]
机构
[1] Hunter Med Res Inst, Prior Res Ctr Asthma & Resp Dis, Newcastle, NSW 2308, Australia
[2] Univ Newcastle, Newcastle, NSW 2308, Australia
关键词
ULCERATIVE-COLITIS; GM-CSF; DISEASE;
D O I
10.1016/j.immuni.2015.07.010
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
Eosinophils are commonly associated with Th2 cell-driven inflammation. In this issue of Immunity, Griseri et al. (2015) identify a new GM-CSF-dependent role for eosinophils in the pathogenesis of IL-23-Th17 cell-induced colitis.
引用
收藏
页码:7 / 9
页数:3
相关论文
共 10 条
[1]
The encephalitogenicity of TH17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF [J].
El-Behi, Mohamed ;
Ciric, Bogoljub ;
Dai, Hong ;
Yan, Yaping ;
Cullimore, Melissa ;
Safavi, Farinaz ;
Zhang, Guang-Xian ;
Dittel, Bonnie N. ;
Rostami, Abdolmohamad .
NATURE IMMUNOLOGY, 2011, 12 (06) :568-U241
[2]
Defective Leukocyte GM-CSF Receptor (CD116) Expression and Function in Inflammatory Bowel Disease [J].
Goldstein, Jonathan I. ;
Kominsky, Douglas J. ;
Jacobson, Nicole ;
Bowers, Brittelle ;
Regalia, Kirsten ;
Austin, Gregory L. ;
Yousefi, Melinda ;
Falta, Michael T. ;
Fontenot, Andrew P. ;
Gerich, Mark E. ;
Golden-Mason, Lucy ;
Colgan, Sean P. .
GASTROENTEROLOGY, 2011, 141 (01) :208-216
[3]
Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis [J].
Griseri, Thibault ;
Arnold, Isabelle C. ;
Pearson, Claire ;
Krausgruber, Thomas ;
Schiering, Chris ;
Franchini, Fanny ;
Schulthess, Julie ;
McKenzie, Brent S. ;
Crocker, Paul R. ;
Powrie, Fiona .
IMMUNITY, 2015, 43 (01) :187-199
[4]
Roles and Regulation of Gastrointestinal Eosinophils in Immunity and Disease [J].
Jung, YunJae ;
Rothenberg, Marc E. .
JOURNAL OF IMMUNOLOGY, 2014, 193 (03) :999-1005
[5]
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease [J].
Kobayashi, T. ;
Okamoto, S. ;
Hisamatsu, T. ;
Kamada, N. ;
Chinen, H. ;
Saito, R. ;
Kitazume, M. T. ;
Nakazawa, A. ;
Sugita, A. ;
Koganei, K. ;
Isobe, K. ;
Hibi, T. .
GUT, 2008, 57 (12) :1682-1689
[6]
Eosinophil granulocytes are activated during the remission phase of ulcerative colitis [J].
Lampinen, M ;
Rönnblom, A ;
Amin, K ;
Kristjansson, G ;
Rorsman, F ;
Sangfelt, P ;
Säfsten, B ;
Wagner, M ;
Wanders, A ;
Winqvist, O ;
Carlson, M .
GUT, 2005, 54 (12) :1714-1720
[7]
CD34 Is Required for Infiltration of Eosinophils into the Colon and Pathology Associated with DSS-Induced Ulcerative Colitis [J].
Maltby, Steven ;
Wohlfarth, Carolin ;
Gold, Matthew ;
Zbytnuik, Lori ;
Hughes, Michael R. ;
McNagny, Kelly M. .
AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (03) :1244-1254
[8]
CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling [J].
Masterson, Joanne C. ;
McNamee, Eoin N. ;
Jedlicka, Paul ;
Fillon, Sophie ;
Ruybal, Joseph ;
Hosford, Lindsay ;
Rivera-Nieves, Jesus ;
Lee, James J. ;
Furuta, Glenn T. .
AMERICAN JOURNAL OF PATHOLOGY, 2011, 179 (05) :2302-2314
[9]
Rectal administration of d-alpha tocopherol for active ulcerative colitis: A preliminary report [J].
Mirbagheri, Seyed Amir ;
Nezami, Behtash Ghazi ;
Assa, Solmaz ;
Hajimahmoodi, Mannan .
WORLD JOURNAL OF GASTROENTEROLOGY, 2008, 14 (39) :5990-5995
[10]
Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice [J].
Mould, AW ;
Matthaei, KI ;
Young, IG ;
Foster, PS .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (05) :1064-1071