Trivalent ion cross-linked pH sensitive alginate-methyl cellulose blend hydrogel beads from aqueous template

被引：52

作者：

Banerjee, Subham ^{[1
,2
]}

Singh, Shivangi ^{[2
]}

Bhattacharya, Shiv Sankar ^{[2
]}

Chattopadhyay, Pronobesh ^{[1
]}

机构：

[1] Def Res Lab, Div Pharmaceut Technol, Tezpur 784001, Assam, India

[2] IFTM Univ, Sch Pharmaceut Sci, Moradabad 244001, Uttar Pradesh, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2013年 / 57卷

关键词：

Emulsion gelation method; Methyl cellulose; Alginate; Trivalent ion; Hydrogel beads; CONTROLLED-RELEASE; IN-VITRO; GUM-POLY(VINYL ALCOHOL); DRUG-RELEASE; GUAR GUM; MICROSPHERES; GELATION; CALCIUM; METHYLCELLULOSE; DELIVERY;

D O I：

10.1016/j.ijbiomac.2013.03.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

pH sensitive alginate-methyl cellulose blend hydrogel beads were prepared by single water-in-water (w/w) emulsion gelation method in a complete aqueous environment. The influence of different variables like total polymer concentration, gelation time and crosslinker content on in vitro physico-chemical characteristics and drug release rate in different medium were investigated. Drug loaded beads were evaluated through Fourier Transform Infra-red (FTIR), X-ray diffraction (XRD) and Differential Scanning Calorimetry (DSC) analysis. Scanning electron microscopy (SEM) picture of the dried beads suggested the formation of hemispherical particles. FTIR analysis indicated the stable nature of the drug in the blend hydrogel beads. DSC and XRD analysis revealed amorphous state of drug after encapsulation. The drug release profile in acidic medium was considerably less in compared in alkaline media. Formulations showed non-Fickian type transport mechanism. This trivalent ion crosslinked beads not only improves drug encapsulation efficiency but also enhances drug release in alkaline media. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：297 / 307

页数：11

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