Preparation of monodisperse colloids of biologically active compounds .1. Naproxen

被引：21

作者：

Pozarnsky, GA ^{[1
]}

Matijevic, E ^{[1
]}

机构：

[1] CLARKSON UNIV,CTR ADV MAT PROC,POTSDAM,NY 13699

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 1997年 / 125卷 / 01期

关键词：

colloidal naproxen; dispersions of drugs; drugs monodispersed; naproxen;

D O I：

10.1016/S0927-7757(97)00012-5

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Uniform submicron particles of (+)-6-methoxy-alpha-methyl-2-napthaleneacetic acid (naproxen) were precipitated by neutralization of basic solutions of the drug in the presence of polyvinylpyrrolidone (PVP). The morphology and size of the resulting particles depended on the polymer stabilizer and on the final ionic strength of the naproxen solution. (C) 1997 Elsevier Science B.V.

引用

页码：47 / 52

页数：6

共 15 条

[1] POLYSTYRENE COLLOIDS WITH SURFACE-GRAFTED POLYETHYLENE OXIDE AS MODEL SYSTEMS FOR SITE-SPECIFIC DRUG-DELIVERY .1. PREPARATION AND SURFACE CHEMICAL CHARACTERIZATION USING SIMS AND XPS
BRINDLEY, A
DAVIS, SS
DAVIES, MC
WATTS, JF
[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1995, 171 (01) : 150 - 161
[2] DANIELS ES, 1992, ACS S SERIES, V492
[3] FLOWER RJ, 1980, PHARMACOL BASIS THER, P710
[4] Guiot P, 1986, POLYM NANOPARTICLES
[5] THE EFFECT OF WETTING AGENTS ON THE DISSOLUTION OF INDOMETHACIN SOLID DISPERSION-SYSTEMS
HILTON, JE
SUMMERS, MP
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 31 (1-2) : 157 - 164
[6] IMAIZUMI H, 1983, CHEM PHARM BULL, V31, P2510
[7] Kawashima Y, 1994, HANDB POWD TECHNOL, V9, P493
[8] KAWASHIMA Y, 1986, J SOC POWDER TECH JA, V23, P719
[9] KIM YB, 1987, ARCH PHARM RES, V10, P323
[10] Liversidge G.G., 1992, USP Pat, Patent No. [5145684, US5145684]

← 1 2 →