Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women

被引：27

作者：

Pare, Guillaume ^{[1
,2
]}

Chasman, Daniel I. ^{[1
,2
]}

Kellogg, Mark ^{[3
]}

Zee, Robert Y. L. ^{[1
,2
]}

Rifai, Nader ^{[3
]}

Badola, Sunita ^{[4
]}

Miletich, Joseph P. ^{[4
]}

Ridker, Paul M. ^{[1
,2
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Cardiovasc Dis Prevent, Boston, MA 02115 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Donald W Reynolds Ctr Cardiovasc Res, Boston, MA 02115 USA

[3] Harvard Univ, Childrens Hosp, Sch Med, Dept Lab Med, Boston, MA 02115 USA

[4] Amgen Inc, Cambridge, MA USA

来源：

PLOS GENETICS | 2008年 / 4卷 / 07期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level ( P, 5610 28), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1610 229) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.

引用

页数：8

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