Human cytotoxic T lymphocyte responses to live attenuated 17D yellow fever vaccine: Identification of HLA-1335-restricted CTL epitopes on nonstructural proteins NS1, NS2b, NS3, and the structural protein E

被引:87
作者
Co, MDT [1 ]
Terajima, M [1 ]
Cruz, J [1 ]
Ennis, FA [1 ]
Rothman, AL [1 ]
机构
[1] Univ Massachusetts, Sch Med, Med Ctr, CIDVR, Worcester, MA 01655 USA
关键词
yellow fever virus; vaccine; HLA-B35; flavivirus; cytotoxic T lymphocyte; epitope; E protein; NS1; protein; NS2b protein; NS3;
D O I
10.1006/viro.2001.1255
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Yellow fever virus (YFV) is a reemerging problem despite the existence of an effective live-attenuated vaccine. The induction of YFV-neutralizing antibodies undoubtedly contributes to vaccine efficacy, but T lymphocyte responses to YFV likely play a role in long-term efficacy. We studied the T lymphocyte responses to YFV in four vaccinees. Proliferation and cytolytic responses to YFV were demonstrated in all subjects. We isolated 13 YFV-specific CD8' CTL lines that recognized epitopes on the E, NS1, NS2b, and NS3 proteins; eight CTL lines were HLA-B35-restricted. YFV-specific T cell responses were detectable by IFNgamma ELISPOT assays 14 days postvaccination, with T cell frequencies sustained for up to 19 months. To our knowledge, this is the first report of human T lymphocyte responses following YFV vaccination. These results indicate that the live 17D YFV vaccine induced CD8(-) T cell responses directed against at least four different HLA-B35-restricted YFV epitopes. (C) 2002 Elsevier Science (USA).
引用
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页码:151 / 163
页数:13
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