Reactome knowledgebase of human biological pathways and processes

被引：587

作者：

Matthews, Lisa ^{[1
]}

Gopinath, Gopal ^{[1
]}

Gillespie, Marc ^{[1
,2
]}

Caudy, Michael ^{[1
]}

Croft, David ^{[3
]}

de Bono, Bernard ^{[3
]}

Garapati, Phani ^{[3
]}

Hemish, Jill ^{[1
]}

Hermjakob, Henning ^{[3
]}

Jassal, Bijay ^{[3
]}

Kanapin, Alex ^{[1
]}

Lewis, Suzanna ^{[4
]}

Mahajan, Shahana ^{[5
,6
]}

May, Bruce ^{[1
]}

Schmidt, Esther ^{[3
]}

Vastrik, Imre ^{[3
]}

Wu, Guanming ^{[1
]}

Birney, Ewan ^{[3
]}

Stein, Lincoln ^{[1
,7
]}

D'Eustachio, Peter ^{[1
,6
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] St Johns Univ, Coll Pharm & Allied Hlth Profess, Jamaica, NY 11439 USA

[3] European Bioinformat Inst, Cambridge CB10 1SD, England

[4] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA

[5] CUNY Hunter Coll, New York, NY 10010 USA

[6] NYU, Sch Med, New York, NY 10016 USA

[7] Ontario Inst Canc Res, Toronto, ON M5G0A3, Canada

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

基金：

美国国家卫生研究院;

关键词：

COLLECTION;

D O I：

10.1093/nar/gkn863

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactome (http://www.reactome.org) is an expert-authored, peer-reviewed knowledgebase of human reactions and pathways that functions as a data mining resource and electronic textbook. Its current release includes 2975 human proteins, 2907 reactions and 4455 literature citations. A new entity-level pathway viewer and improved search and data mining tools facilitate searching and visualizing pathway data and the analysis of user-supplied high-throughput data sets. Reactome has increased its utility to the model organism communities with improved orthology prediction methods allowing pathway inference for 22 species and through collaborations to create manually curated Reactome pathway datasets for species including Arabidopsis, Oryza sativa (rice), Drosophila and Gallus gallus (chicken). Reactome's data content and software can all be freely used and redistributed under open source terms.

引用

页码：D619 / D622

页数：4

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