Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer

被引：168

作者：

Injac, Rade ^{[1
]}

Perse, Martina ^{[2
]}

Cerne, Manica ^{[3
]}

Potocnik, Nejka ^{[4
]}

Radic, Natasa ^{[1
]}

Govedarica, Biljana ^{[5
]}

Djordjevic, Aleksandar ^{[6
]}

Cerar, Anton ^{[2
]}

Strukelj, Borut ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Pharm, Inst Pharmaceut Biol, Ljubljana 1000, Slovenia

[2] Univ Ljubljana, Inst Pathol, Ctr Med Expt, Fac Med, Ljubljana 1000, Slovenia

[3] Univ Ljubljana, Inst Pathol Forens & Adm Vet Med, Fac Vet, Ljubljana 1000, Slovenia

[4] Univ Ljubljana, Sch Med, Inst Physiol, Ljubljana 1000, Slovenia

[5] Univ Ljubljana, Fac Pharm, Inst Pharmaceut Technol, Ljubljana 1000, Slovenia

[6] Univ Novi Sad, Fac Sci, Dept Chem, Novi Sad 21000, Serbia

来源：

BIOMATERIALS | 2009年 / 30卷 / 06期

关键词：

Doxorubicin; Cardiotoxicity; Hepatotoxicity; Fullerenol; Oxidative stress; Colorectal cancer; VITAMIN-E; WATER SUSPENSIONS; IN-VIVO; ANTIOXIDANT; TOXICITY; DAMAGE; SUPPRESSION; AMIFOSTINE; PARAMETERS; ACID;

D O I：

10.1016/j.biomaterials.2008.10.060

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The effects of fullerenol C-60(OH)(24) (Frl) at closes of 25, 50, and 100 mg/kg/week (for a time-span of 3 weeks) on heart and liver tissue after doxorubicin (Dox)-induced toxicity in rats with colorectal cancer were investigated. In the present study, we used an in vivo Wistar male rat model to explore whether Frl could protect against Dox-induced (1.5 mg/kg/week for 3 weeks) chronic cardio- and hepato- toxicity and compared the effect with a well-known antioxidant, vitamin C (100 mg/kg/week for 3 weeks). According to macroscopic, microscopic, hematological, biochemical, physiological, pharmacological, and phamacokinetic results, we confirmed that, at all examined doses, Frl exhibits a protective influence on the heart and liver tissue against chronic toxicity induced by Dox. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1184 / 1196

页数：13

共 55 条

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Role of Nigella sativa and a Number of its Antioxidant Constituents towards Azoxymethane-induced Genotoxic Effects and Colon Cancer in Rats [J].