Antibiotic resistance from two perspectives: man and microbe

Despite much effort, antibiotic resistance continues to increase. Looking back, it is clear that this was an inevitable consequence of antibiotic use. From a bacterial viewpoint, the introduction of antibiotics was a tremendous stimulus to evolution. As a survival reaction to stress (selection pressure) bacteria, by means of their extreme biochemical and genetic versatility, have adapted to 21st Century conditions. Resistance can be to some extent contained by less and better use of antibiotics, but ultimately novel approaches to the treatment and prevention of infectious diseases will have to be forthcoming. This will only be achieved if best use is made of alternative resources presently available and most importantly, man's ingenuity must be fully engaged. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.