The Clinical Utilization of Circulating Cell Free DNA (CCFDNA) in Blood of Cancer Patients

被引：204

作者：

Elshimali, Yahya I. ^{[1
]}

Khaddour, Husseina ^{[2
]}

Sarkissyan, Marianna ^{[1
]}

Wu, Yanyuan ^{[1
,3
]}

Vadgama, Jaydutt V. ^{[1
,3
]}

机构：

[1] Charles R Drew Univ Med & Sci, Dept Internal Med, Div Canc Res & Training, Los Angeles, CA 90059 USA

[2] Damascus Univ, Fac Pharm, Lab Diagnost Med, Damascus, Syria

[3] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 09期

关键词：

circulating cell free DNA; neoplasms; early diagnosis; follow up on cancer treatment; prognosis; FREE SERUM DNA; FREE NUCLEIC-ACIDS; FREE PLASMA DNA; INDEPENDENT PROGNOSTIC MARKER; TUMOR-SUPPRESSOR GENES; BREAST-CANCER; COLORECTAL-CANCER; PROSTATE-CANCER; PERIPHERAL-BLOOD; QUANTITATIVE-ANALYSIS;

D O I：

10.3390/ijms140918925

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Qualitative and quantitative testing of circulating cell free DNA (CCFDNA) can be applied for the management of malignant and benign neoplasms. Detecting circulating DNA in cancer patients may help develop a DNA profile for early stage diagnosis in malignancies. The technical issues of obtaining, using, and analyzing CCFDNA from blood will be discussed.

引用

页码：18925 / 18958

页数：34

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