Apolipoprotein E4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer's disease

被引：46

作者：

Kanai, M

Shizuka, M

Urakami, K

Matsubara, E

Harigaya, Y

Okamoto, K

Shoji, M

机构：

[1] Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan

[2] Tottori Univ, Fac Med, Div Neurol, Inst Neurol Sci, Yonago, Tottori 6838504, Japan

来源：

NEUROSCIENCE LETTERS | 1999年 / 267卷 / 01期

关键词：

Alzheimer's disease; apolipoprotein E4; cerebrospinal fluid; tau; A beta;

D O I：

10.1016/S0304-3940(99)00323-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To examine the effect of apolipoprotein E (ApoE) 4 on the progression of Alzheimer's disease (AD), the clinical course of 33 AD patients (17 cases with ApoE epsilon 4 and 16 cases without ApoE epsilon 4) was evaluated with the mini-mental state examination (MMSE) and cerebrospinal fluid (CSF) biological markers. The decline of MMSE scores to zero was shortened in the ApoE4 group. During a mean follow-up of 20 months, a significant increase of CSF tau levels was observed in the ApoE4 group. A lower level of CSF A beta 1-42(43) was found in both the ApoE4 and non-ApoE4 groups than in age-matched normal controls. The ApoE epsilon 4 allele accelerates the progression of dementia and increases the levels of CSF tau in AD patients. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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页码：65 / 68

页数：4

相关论文

共 20 条

[1] Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition [J].

Bales, KR ;

Verina, T ;

Dodel, RC ;

Du, YS ;

Altstiel, L ;

Bender, M ;

Hyslop, P ;

Johnstone, EM ;

Little, SP ;

Cummins, DJ ;

Piccardo, P ;

Ghetti, B ;

Paul, SM .

NATURE GENETICS, 1997, 17 (03) :263-264

[2] FIBRILLOGENESIS IN ALZHEIMERS-DISEASE OF AMYLOID-BETA PEPTIDES AND APOLIPOPROTEIN-E [J].

CASTANO, EM ;

PRELLI, F ;

WISNIEWSKI, T ;

GOLABEK, A ;

KUMAR, RA ;

SOTO, C ;

FRANGIONE, B .

BIOCHEMICAL JOURNAL, 1995, 306 :599-604

[3] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[4] Accelerated decline in apolipoprotein E-ε4 homozygotes with Alzheimer's disease [J].

Craft, S ;

Teri, L ;

Edland, SD ;

Kukull, WA ;

Schellenberg, G ;

McCormick, WC ;

Bowen, JD ;

Larson, EB .

NEUROLOGY, 1998, 51 (01) :149-153

[5] GENE DOSE OF THE EPSILON-4 ALLELE OF APOLIPOPROTEIN-E AND DISEASE PROGRESSION IN SPORADIC LATE-ONSET ALZHEIMERS-DISEASE [J].

FRISONI, GB ;

GOVONI, S ;

GEROLDI, C ;

BIANCHETTI, A ;

CALABRESI, L ;

FRANCESCHINI, G ;

TRABUCCHI, M .

ANNALS OF NEUROLOGY, 1995, 37 (05) :596-604

[6] High cerebrospinal fluid tau and low amyloid β42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype [J].

Galasko, D ;

Chang, L ;

Motter, R ;

Clark, CM ;

Kaye, J ;

Knopman, D ;

Thomas, R ;

Kholodenko, D ;

Schenk, D ;

Lieberburg, I ;

Miller, B ;

Green, R ;

Basherad, R ;

Kertiles, L ;

Boss, MA ;

Seubert, P .

ARCHIVES OF NEUROLOGY, 1998, 55 (07) :937-945

[7] Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease [J].

GomezIsla, T ;

West, HL ;

Rebeck, GW ;

Harr, SD ;

Growdon, JH ;

Locascio, JJ ;

Perls, TT ;

Lipsitz, LA ;

Hyman, BT .

ANNALS OF NEUROLOGY, 1996, 39 (01) :62-70

[8] Apolipoprotein E accumulates with the progression of A beta deposition in transgenic mice [J].

Igeta, Y ;

Kawarabayashi, T ;

Sato, M ;

Yamada, N ;

Matsubara, E ;

Ishiguro, K ;

Kanai, M ;

Tomidokoro, Y ;

Osuga, J ;

Okamoto, K ;

Hirai, S ;

Shoji, M .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1997, 56 (11) :1228-1235

[9] Association between apolipoprotein E ε4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia [J].

Jonker, C ;

Schmand, B ;

Lindeboom, J ;

Havekes, LM ;

Launer, LJ .

ARCHIVES OF NEUROLOGY, 1998, 55 (08) :1065-1069

[10] Longitudinal study of cerebrospinal fluid levels of tau, Aβ1-40, and Aβ1-42(43) in Alzheimer's disease:: A study in Japan [J].

Kanai, M ;

Matsubara, E ;

Isoe, K ;

Urakami, K ;

Nakashima, K ;

Arai, H ;

Sasaki, H ;

Abe, K ;

Iwatsubo, T ;

Kosaka, T ;

Watanabe, M ;

Tomidokoro, Y ;

Shizuka, M ;

Mizushima, K ;

Nakamura, T ;

Igeta, Y ;

Ikeda, Y ;

Amari, M ;

Kawarabayashi, T ;

Ishiguro, K ;

Harigaya, Y ;

Wakabayashi, K ;

Okamoto, K ;

Hirai, S ;

Shoji, M .

ANNALS OF NEUROLOGY, 1998, 44 (01) :17-26