Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp FKI-1938

被引：11

作者：

Fukuda, Takashi ^{[2
,3
]}

Hasegawa, Yoko ^{[2
,3
]}

Sakabe, Yasunari ^{[2
,3
]}

Tomoda, Hiroshi ^{[1
]}

Omura, Satoshi ^{[2
,3
]}

机构：

[1] Kitasato Univ, Sch Pharm, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[3] Kitasato Univ, Grad Sch Infect Control Sci, Minato Ku, Tokyo 1088641, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 09期

关键词：

citrinamide; miconazole potentiator; Penicillium sp; fungal metabolite; Candida albicans;

D O I：

10.1038/ja.2008.73

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new aromatic alkaloids, designated citrinamides A and B, were isolated from the culture broth of Penicillium sp. FKI-1938 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analysis, including NMR and amino acid analysis. Citrinamides A and B showed moderate potentiation of miconazole activity against Candida albicans.

引用

页码：550 / 555

页数：6

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