Nipah virus-assodiated encephalitis outbreak, Siliguri, India

被引：366

作者：

Chadha, MS

Comer, JA

Lowe, L

Rota, PA

Rollin, PE

Bellini, WJ

Ksiazek, TG

Mishra, AC

机构：

[1] Natl Inst Virol, Pune 411001, Maharashtra, India

[2] Ctr Dis Control & Prevent, Atlanta, GA USA

来源：

EMERGING INFECTIOUS DISEASES | 2006年 / 12卷 / 02期

关键词：

D O I：

10.3201/eid1202.051247

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During January and February 2001, an outbreak of febrile illness associated with altered sensorium was observed in Siliguri, West Bengal, India. Laboratory investigations at the time of the outbreak did not identify an infectious agent. Because Siliguri is in close proximity to Bangladesh, where outbreaks of Nipah virus (NiV) infection were recently described, clinical material obtained during the Siliguri outbreak was retrospectively analyzed for evidence of NiV infection. NiV-specific immunoglobulin M (IgM) and IgG antibodies were detected in 9 of 18 patients. Reverse transcription-polymerase chain reaction (RTPCR) assays detected RNA from NiV in urine samples from 5 patients. Sequence analysis confirmed that the PCR products were derived from NiV RNA and suggested that the NiV from Siliguri was more closely related to NiV isolates from Bangladesh than to NiV isolates from Malaysia. NiV infection has not been previously detected in India.

引用

页码：235 / 240

页数：6

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