A convenient procedure for the preparation of α-aminoallenes using a three-component reaction of aldehyde, carbamate and propargylsilane

被引：27

作者：

Billet, M ^{[1
]}

Schoenfelder, A ^{[1
]}

Klotz, P ^{[1
]}

Mann, A ^{[1
]}

机构：

[1] Lab Pharmacochim Commun Cellulaire, UMR 7081, F-67401 Illkirch Graffenstaden, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(02)00056-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-component reaction is described using an aldehyde, a carbamate and trimethylpropargylsilane in the presence of a Lewis acid for the production in moderate to good yield of alpha-allenyl amines. The reaction is applicable to aromatic or aliphatic aldehydes, The obtained alpha-aminoallenes are transformed into Delta(3)-pyrrolidines or amino acids by Using the reactivity of the cumulene function. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1453 / 1456

页数：4

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