Hypertension

被引：810

作者：

Poulter, Neil R. ^{[1
]}

Prabhakaran, Dorairaj ^{[2
]}

Caulfield, Mark ^{[3
,4
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Int Ctr Circulatory Hlth, London W2 1LA, England

[2] Fdn India, Ctr Chron Dis Control & Publ Hlth, New Delhi, India

[3] Queen Mary Univ London, William Harvey Res Inst, London, England

[4] Queen Mary Univ London, NIHR Biomed Res Unit Cardiovasc Dis Barts, London, England

来源：

LANCET | 2015年 / 386卷 / 9995期

关键词：

AMBULATORY BLOOD-PRESSURE; ALDOSTERONE-PRODUCING ADENOMAS; TRANSIENT ISCHEMIC ATTACK; CARDIOVASCULAR-DISEASE; RISK-FACTORS; RENAL DENERVATION; EUROPEAN-SOCIETY; URINARY SODIUM; GLOBAL BURDEN; ANTIHYPERTENSIVE THERAPY;

D O I：

10.1016/S0140-6736(14)61468-9

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Raised blood pressure is the biggest single contributor to the global burden of disease and to global mortality. The numbers of people affected and the prevalence of high blood pressure worldwide are expected to increase over the next decade. Preventive strategies are therefore urgently needed, especially in less developed countries, and management of hypertension must be optimised. Genetic advances in some rare causes of hypertension have been made lately, but the aggregate effect on blood pressure of all the genetic loci identified to date is small. Hence, intervention on key environmental determinants and effective implementation of trial-based therapies are needed. Three-drug combinations can control hypertension in about 90% of patients but only if resources allow identification of patients and drug delivery is affordable. Furthermore, assessment of optimal drug therapy for each ethnic group is needed.

引用

页码：801 / 812

页数：12

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