Can NK cells be a therapeutic target in human cancer?

被引：24

作者：

Chan, Christopher J. ^{[1
]}

Andrews, Daniel M. ^{[1
]}

Smyth, Mark J. ^{[1
]}

机构：

[1] Peter MacCallum Canc Ctr, East Melbourne, Australia

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2008年 / 38卷 / 11期

基金：

英国医学研究理事会;

关键词：

Cancer; Immunosurveillance; NK cells; Therapy;

D O I：

10.1002/eji.200838764

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our current knowledge of NK-cell recognition and effector function suggests that it will be possible to design various new NK-cell-based immunotherapies against human cancer. The application of NK cells is already showing promise using HLA-mismatched haematopoietic stem cell transplantation for treatment of haematological malignancies. A better understanding of NK-cell heterogeneity and function will only broaden the applications for human cancer. Here we review the key developments that will propel this field.

引用

页码：2964 / 2968

页数：5

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