Mutation analysis of the c-mos proto-oncogene and the endothelin-B receptor gene in medullary thyroid carcinoma and phaeochromocytoma

被引：11

作者：

Eng, C

Foster, KA

Healey, CS

Houghton, C

Gayther, SA

Mulligan, LM

Ponder, BAJ

机构：

[1] UNIV CAMBRIDGE,CRC,HUMAN CANC GENET RES GRP,CAMBRIDGE CB2 2QQ,ENGLAND

[2] QUEENS UNIV,DEPT PATHOL,KINGSTON,ON K7L 3N6,CANADA

[3] QUEENS UNIV,DEPT PAEDIAT,KINGSTON,ON K7L 3N6,CANADA

来源：

BRITISH JOURNAL OF CANCER | 1996年 / 74卷 / 03期

关键词：

MEN; 2; RET; c-mos; endothelin-B receptor; medullary thyroid carcinoma; phaeochromocytoma;

D O I：

10.1038/bjc.1996.363

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The characteristic tumours of MEN 2 are medullary thyroid carcinoma (MTC) and phaeochromocytoma. Somatic RET mutations have been found in only 23-40% of sporadic IWTC and 10% of sporadic phaeochromocytomas. Thus, we sought other genes which may play a role in the pathogenesis of these tumours. We carried out direct sequence analysis of human c-mos and human ENRB in a series of sporadic MTC and phaeochromocytomas to determine if somatic mutations in these two genes could account for some of the sporadic MEN 2-related tumours in which no RET mutations are detected. No somatic mutations were found.

引用

页码：339 / 341

页数：3

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