Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist

被引：175

作者：

Niemeyer, Daniela ^{[1
]}

Zillinger, Thomas ^{[2
]}

Muth, Doreen ^{[1
]}

Zielecki, Florian ^{[3
]}

Horvath, Gabor ^{[4
]}

Suliman, Tasnim ^{[1
]}

Barchet, Winfried ^{[2
]}

Weber, Friedemann ^{[3
]}

Drosten, Christian ^{[1
]}

Mueller, Marcel A. ^{[1
]}

机构：

[1] Univ Bonn, Med Ctr, Inst Virol, Bonn, Germany

[2] Univ Bonn, Med Ctr, Inst Clin Chem & Clin Pharmacol, Bonn, Germany

[3] Univ Marburg, Inst Virol, D-35032 Marburg, Germany

[4] Univ Bonn, Med Ctr, Inst Innate Immun, Bonn, Germany

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 22期

关键词：

DOUBLE-STRANDED-RNA; RIG-I; PHOSPHOPROTEIN-P; NSS PROTEIN; IDENTIFICATION; LOCALIZATION; INHIBITION; STAT1; SELF;

D O I：

10.1128/JVI.01845-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA.

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收藏

页码：12489 / 12495

页数：7

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