Complement and its role in protection and pathogenesis of flavivirus infections

被引：48

作者：

Avirutnan, Panisadee ^{[1
,4
]}

Mehlhop, Erin ^{[2
]}

Diamond, Michael S. ^{[1
,2
,3
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[4] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Res & Dev,Med Mol Biol Unit, Bangkok 10700, Thailand

来源：

VACCINE | 2008年 / 26卷

关键词：

Virus; Innate Immunity; Dengue; West Nile; Immune Evasion;

D O I：

10.1016/j.vaccine.2008.11.061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review. we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：I100 / I107

页数：8

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