Replication of chronic abnormal cartilage loading by medial meniscus destabilization for modeling osteoarthritis in the rabbit knee in vivo

被引:35
作者
Arunakul, Marut [1 ,2 ]
Tochigi, Yuki [1 ,3 ]
Goetz, Jessica E. [1 ,4 ]
Diestelmeier, Bryce W. [1 ,4 ]
Heiner, Anneliese D. [1 ,4 ]
Rudert, James [1 ]
Fredericks, Douglas C. [1 ]
Brown, Thomas D. [1 ,4 ]
McKinley, Todd O. [1 ,5 ]
机构
[1] Univ Iowa, Dept Orthopaed & Rehabil, Orthopaed Biomech Lab, Iowa City, IA 52242 USA
[2] Thammasat Univ, Dept Orthopaed Surg, Pathum Thani, Thailand
[3] Dokkyo Med Univ, Koshigaya Hosp, Dept Orthopaed, Koshigaya, Saitama, Japan
[4] Univ Iowa, Dept Biomed Engn, Iowa City, IA 52242 USA
[5] Indiana Univ Hlth Orthopaed & Sports Med, Indianapolis, IN USA
关键词
post-traumatic osteoarthritis; survival animal model; rabbit knee; meniscus; contact stress; POSTTRAUMATIC OSTEOARTHRITIS; JOINT INJURY; MENISCECTOMY; TRANSECTION; STRESS; FRACTURES; EXTRUSION; LIGAMENT; IMPACT; MOTION;
D O I
10.1002/jor.22393
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
100224 [整形外科学];
摘要
Medial meniscus destabilization (MMD) is a surgical insult technique for modeling osteoarthritis (OA) by replicating chronic abnormal cartilage loading in animal joints in vivo. The present study aimed to characterize the immediate biomechanical effects (ex vivo) and short-term histological consequences (in vivo) of MMD in the rabbit knee. In a compressive loading test, contact stress distribution in the medial compartment was measured in eight cadaver rabbit knees, initially with all major joint structures uninjured (Baseline), after MMD, and finally after total medial meniscectomy (TMM). Similarly, the effects on sagittal joint stability were determined in an anterior-posterior drawer test. These biomechanical (ex vivo) data indicated that both MMD and TMM caused significant (p<0.001), distinct (>1.5-fold) elevation of peak local contact stress in the medial compartment, while leaving whole-joint stability nearly unchanged. Histological consequences in vivo were assessed in a short-term (8-week) survival series of MMD or TMM (five animals for each group), and both caused moderate cartilage degeneration in the medial compartment. The MMD insult, which is feasible through posterior arthrotomy alone, is as effective as TMM for modeling injurious-level chronic abnormal cartilage loading in the rabbit knee medial compartment in vivo, while minimizing potential confounding effects from whole-joint instability. (c) 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1555-1560, 2013.
引用
收藏
页码:1555 / 1560
页数:6
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