Fluoroquinolones: Mechanism of action, classification, and development of resistance

被引：253

作者：

Blondeau, JM

机构：

[1] Royal Univ Hosp, Dept Clin Microbiol, Saskatoon, SK S7N 0W8, Canada

[2] Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK, Canada

[3] Univ Saskatchewan, Dept Pathol, Saskatoon, SK S7N 0W0, Canada

来源：

SURVEY OF OPHTHALMOLOGY | 2004年 / 49卷

关键词：

antimicrobials; fluoroquinolones; mechanisms of action; ocular infections; resistance topoisomerases;

D O I：

10.1016/j.survophthal.2004.01.005

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The fluoroquinolones represent an evolving class of broad-spectrum antimicrobial agents used in the prevention and treatment of a variety of ocular infections; however, resistance to currently available agents in the class has been emerging among ocular pathogens. This article reviews the mechanism of action of existing and new fluoroquinolones and discusses the structure-activity relationship of the fluoroquinolones as it relates to the classification of these compounds. This article also highlights the mechanism of resistance among common ocular pathogens and discusses the potential need for newer fluoroquinolones in ophthalmology. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：S73 / S78

页数：6

共 39 条

[1] The fluoroquinolone antibacterials: past, present and future perspectives [J].