Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases

被引：382

作者：

Togo, T

Akiyama, H

Iseki, E

Kondo, H

Ikeda, K

Kato, M

Oda, T

Tsuchiya, K

Kosaka, K

机构：

[1] Tokyo Inst Psychiat, Setagaya Ku, Tokyo 1568585, Japan

[2] Yokohama City Univ, Dept Psychiat, Yokohama, Kanagawa 232, Japan

[3] Soga Hosp, Odawara, Kanagawa, Japan

[4] Natl Shimofusa Sanatorium, Chiba, Japan

[5] Tokyo Metropolitan Matsuzawa Hosp, Tokyo, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 124卷 / 1-2期

关键词：

lymphocyte; immune surveillance; inflammation; phenotype;

D O I：

10.1016/S0165-5728(01)00496-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the occurrence of T cells in the brain parenchyma of Alzheimer's disease (AD), non-AD degenerative dementias and controls by semi-quantitative analysis of immunohistochemically stained tissue sections. In all cases, we found at least some T cells. The number of T cells was increased in the majority of AD cases compared with other cases. The phenotype of T cells in the AD brain indicates that they are activated but are not fully differentiated. Antigen-triggered clonal expansion is not likely to take place. Local inflammatory conditions might cause accumulation and activation of T cells in the AD brain. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：83 / 92

页数：10

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