Linear type azo-containing polyurethanes for colon-specific drug delivery

被引：23

作者：

Mahkam, M ^{[1
]}

Assam, MG

Zahedifar, R

Ramesh, M

Davaran, S

机构：

[1] Azarbaijan Univ Tarbiat Moallem, Fac Sci, Dept Chem, Tabriz, Iran

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2004年 / 19卷 / 01期

关键词：

biodegradable; polymeric prodrug; 5-aminosalicylic acid; hydrolysis; pH sensitive;

D O I：

10.1177/0883911504041602

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

New biodegradable polyurethanes containing azo-linked polymeric prodrugs of 5-aminosaheylic acid (5-ASA) in the main chain were prepared by reacting 1,6-Hexamethylenediisocyanate (HDI) with 3,3'-azobis(6-hydroxy benzoic acid) (ABHB) and 5-[4-(hydroxyl phenyl) azol salicylic acid (HPAS) as azo derivatives of 5-ASA. The polymers were characterized by FTIR and H-1-NMR spectroscopy. The hydrolysis of polyurethane containing azo-derivatives of 5-ASA was carried out in cellophane membrane dialysis bags containing aqueous buffer solution (pH = 8.5 and pH = 1) at 37degreesC. Detection of the hydrolysis product by UV spectroscopy showed that ABHB and HPAS were released by the hydrolysis of the urethane bond in the polymer chain.

引用

页码：45 / 53

页数：9

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