Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes - a randomized controlled trial

被引:103
作者
Daly, ME
Paisey, R
Paisey, R
Millward, BA
Eccles, C
Williams, K
Hammersley, S
MacLeod, KM
Gale, TJ
机构
[1] Royal Devon & Exeter NHS Trust, Diabet & Vasc Hlth Ctr, Exeter EX2 5DW, Devon, England
[2] Torbay Hosp, Torquay, England
[3] Derriford Hosp, Plymouth PL6 8DH, Devon, England
[4] Univ Plymouth, Peninsula Med Sch, Plymouth, Devon, England
[5] Univ Exeter, Peninsula Med Sch, Exeter EX4 4QJ, Devon, England
关键词
dietary carbohydrate; weight loss; Type; 2; diabetes; obesity; lipids;
D O I
10.1111/j.1464-5491.2005.01760.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective This study sought to examine the effects of a 3-month programme of dietary advice to restrict carbohydrate intake compared with reduced-portion, low-fat advice in obese subjects with poorly controlled Type 2 diabetes. Research design and methods One hundred and two patients with Type 2 diabetes were recruited across three centres and randomly allocated to receive group education and individual dietary advice. Weight, glycaemic control, lipids and blood pressure were assessed at baseline and 3 months. Dietary quality was assessed at the end of study. Results Weight loss was greater in the low-carbohydrate (LC) group (-3.55 +/- 0.63, mean +/- SEM) vs. -0.92 +/- 0.40 kg, P = 0.001) and cholesterol : high-density lipoprotein (HDL) ratio improved (-0.48 +/- 0.11 vs. -0.10 +/- 0.10, P = 0.01). However, relative saturated fat intake was greater (13.9 +/- 0.71 vs. 11.0 +/- 0.47% of dietary intake, P < 0.001), although absolute intakes were moderate. Conclusions Carbohydrate restriction was an effective method of achieving short-term weight loss compared with standard advice, but this was at the expense of an increase in relative saturated fat intake.
引用
收藏
页码:15 / 20
页数:6
相关论文
共 29 条
[1]  
Astrup A, 2000, BRIT J NUTR, V83, pS25
[2]   A RANDOMIZED CONTROLLED TRIAL OF LOW CARBOHYDRATE AND LOW FAT HIGH-FIBER DIETS FOR WEIGHT-LOSS [J].
BARON, JA ;
SCHORI, A ;
CROW, B ;
CARTER, R ;
MANN, JI .
AMERICAN JOURNAL OF PUBLIC HEALTH, 1986, 76 (11) :1293-1296
[3]   A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women [J].
Brehm, BJ ;
Seeley, RJ ;
Daniels, SR ;
D'Alessio, DA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (04) :1617-1623
[4]   RELATIONSHIP OF ANIMAL PROTEIN-RICH DIET TO KIDNEY-STONE FORMATION AND CALCIUM-METABOLISM [J].
BRESLAU, NA ;
BRINKLEY, L ;
HILL, KD ;
PAK, CYC .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 66 (01) :140-146
[5]  
Department of Health, 1991, DIET REF VAL FOOD EN
[6]   Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women [J].
Farnsworth, E ;
Luscombe, ND ;
Noakes, M ;
Wittert, G ;
Argyiou, E ;
Clifton, PM .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2003, 78 (01) :31-39
[7]  
*FOR SOFTW L, 2002, DIETPLAN5 WIND
[8]   A randomized trial of a low-carbohydrate diet for obesity [J].
Foster, GD ;
Wyatt, HR ;
Hill, JO ;
McGuckin, BG ;
Brill, C ;
Mohammed, BS ;
Szapary, PO ;
Rader, DJ ;
Edman, JS ;
Klein, S .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (21) :2082-2090
[9]  
Giannini S, 1999, AM J CLIN NUTR, V69, P267
[10]  
Golay A, 1996, INT J OBESITY, V20, P1067