Multifactorial basis for coronary collateralization: a complex adaptive response to ischemia

被引：53

作者：

Kersten, JR

Pagel, PS

Chilian, WM

Warltier, DC

机构：

[1] Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Dept Physiol & Med, Div Cardiovasc Dis, Milwaukee, WI 53226 USA

[4] Vet Affairs Med Ctr, Milwaukee, WI 53226 USA

来源：

CARDIOVASCULAR RESEARCH | 1999年 / 43卷 / 01期

关键词：

angiogenesis; coronary collateral; growth factors; myocardial ischemia; vasculogenesis;

D O I：

10.1016/S0008-6363(99)00077-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiogenesis and vasculogenesis are adaptive responses of the coronary collateral circulation to myocardial ischemia. This review focuses on the concerted action of growth factors, growth factor receptors. extracellular matrix, and inflammatory cellular responses to regulate angiogenesis and vasculogenesis in response to myocardial ischemia and alterations in sheer stress, Therapeutic angiogenesis represents a novel approach to increase myocardial perfusion in patients with coronary artery disease and provides an opportunity to further clarify the mechanisms that regulate collateral development. Impairment of angiogenic adaptive responses to ischemia during disease states is an important subject for future investigation. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：44 / 57

页数：14

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