Inhibitors of HIV-1 protease by using in situ click chemistry

被引：494

作者：

Whiting, M

Muldoon, J

Lin, YC

Silverman, SM

Lindstrom, W

Olson, AJ

Kolb, HC

Finn, MG

Sharpless, KB

Elder, JH

Fokin, VV

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 09期

关键词：

click chemistry; drug design; HIV-1; protease; inhibitors; triazoles;

D O I：

10.1002/anie.200502161

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Twice poor equals potent: HIV-1 Protease assembles its own potent inhibitor through formation of the triazole linkage from azide- and alkyne-containing fragments that are themselves poor binders. © 2006 Wiley-VCH Verlag GmbH S. Co. KGaA.

引用

收藏

页码：1435 / 1439

页数：5

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