Formation of Aryl-bis (6-Amino-1,3-Dimethyluracil-5-yl) Methanes by reaction of 6-Amino-1, 3-Dimethyluracil with Aromatic Aldehydes

被引：22

作者：

Bansal, Ranju ^{[1
]}

Kumar, R. Sunil ^{[1
]}

Kumar, Gulshan ^{[1
]}

Thota, Sridhar ^{[1
]}

Thamotharan, S. ^{[2
]}

Parthasarathi, V. ^{[3
]}

Linden, Anthony ^{[4
]}

机构：

[1] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India

[2] Indian Inst Sci, Mol Biophys Unit, Bangalore 560012, Karnataka, India

[3] Bharathidasan Univ, Sch Phys, Tiruchirappalli 620024, India

[4] Univ Zurich, Inst Organ Chem, CH-8057 Zurich, Switzerland

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2008年 / 45卷 / 06期

关键词：

D O I：

10.1002/jhet.5570450636

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

The synthesis of aryl-bis(6-amino-1,3-dimethyluracil-5-yl)-methanes 3a-m by condensation of 6-amino-1,3-dimethyluracil (1) with aromatic aldehydes 2a-m at room temperature is reported. The structures of the compounds were established using various spectroscopic analyses and X-ray crystallography. The crystal structures of two aryl-bis (6-amino-1,3-dimethyluracil-5-yl) methanes are presented.

引用

页码：1789 / 1795

页数：7

共 17 条

[1]

Novel pyrazolo[3,4-d]pyrimidine-based inhibitors of Staphlococcus aureus DNA polymerase III:: Design, synthesis, and biological evaluation [J].

Ali, A ;

Taylor, GE ;

Ellsworth, K ;

Harris, G ;

Painter, R ;

Silver, LL ;

Young, K .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (10) :1824-1830

[2]

SIR92 - a program for automatic solution of crystal structures by direct methods [J].

ALTOMARE, A ;

CASCARANO, G ;

GIACOVAZZO, G ;

GUAGLIARDI, A ;

BURLA, MC ;

POLIDORI, G ;

CAMALLI, M .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1994, 27 :435-435

[3]

BARNETTE MS, 1999, PROG DRUG RES, V53, P195

[4]

PATTERNS IN HYDROGEN BONDING - FUNCTIONALITY AND GRAPH SET ANALYSIS IN CRYSTALS [J].

BERNSTEIN, J ;

DAVIS, RE ;

SHIMONI, L ;

CHANG, NL .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1995, 34 (15) :1555-1573

[5]

IMIDAZOLE DERIVATIVES AS INHIBITORS OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES [J].

BUCHMAN, R ;

HEINSTEIN, PF ;

WELLS, JN .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (11) :1168-1173

[6]

INHIBITION OF CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE BY DERIVATIVES OF 1,3-BIS(CYCLOPROPYLMETHYL)XANTHINE [J].

BUCKLE, DR ;

ARCH, JRS ;

CONOLLY, BJ ;

FENWICK, AE ;

FOSTER, KA ;

MURRAY, KJ ;

READSHAW, SA ;

SMALLRIDGE, M ;

SMITH, DG .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (04) :476-485

[7]

Farrugia L.J., 1997, J APPL CRYSTALLOGR, V30, P565

[8]

INHIBITION OF SEPARATED FORMS OF PHOSPHODIESTERASES FROM PIG CORONARY-ARTERIES BY URACILS AND BY 7-SUBSTITUTED DERIVATIVES OF 1-METHYL-3-ISOBUTYLXANTHINE [J].

GARST, JE ;

KRAMER, GL ;

WU, YJ ;

WELLS, JN .

JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (04) :499-503

[9]

An update on cyclic nucleotide phosphodiesterase (PDE) inhibitors: Phosphodiesterases and drug selectivity [J].

Gupta, R ;

Kumar, G ;

Kumar, RS .

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, 2005, 27 (02) :101-118

[10]

MULLER CE, 1993, J MED CHEM, V36, P3341

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