Determination of in vitro antidiabetic effects of Zingiber officinale Roscoe

被引：10

作者：

Sattar, Naila Abdul ^{[1
]}

Hussain, Fatma ^{[1
]}

Iqbal, Tahira ^{[1
]}

Sheikh, Munir Ahmad ^{[1
]}

机构：

[1] Univ Agr Faisalabad, Fac Sci, Dept Chem & Biochem, Faisalabad, Pakistan

来源：

BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2012年 / 48卷 / 04期

关键词：

Zingiber officinale/pharmacognosy; Zingiber officinale/antidiabetic effects/in vitro study; Diabetes mellitus; Hyperglycemia; Proteins/glycation; Glucose/diffusion in vitro; INDUCED DIABETIC-RATS; NONENZYMATIC GLYCATION; DIETARY FIBER; GINGER; GLUCOSE; COMPLICATIONS; DIFFUSION; PROTEINS; MELLITUS; EXTRACT;

D O I：

10.1590/S1984-82502012000400003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aqueous extracts of Zingiber officinale rhizomes were studied to evaluate their antidiabetic effects on protein glycation and on the diffusion of glucose in vitro in the present study. Zingiber officinale rhizome aqueous extract were examined at concentrations of 5, 10, 20 and 40 g/L. The antidiabetic effects were found to be dose-dependent. Antidiabetic potential of Zingiber officinale was mainly through inhibition of the glucose diffusion and to a limited extent by reducing the glycation. However, further studies are needed to determine in vitro effects of therapeutic potential by restraining postprandial glucose absorptions and plasma protein glycations in diabetic subjects.

引用

页码：601 / 607

页数：7

共 40 条

[1]

Afzal M, 2001, Drug Metabol Drug Interact, V18, P159

[2] Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats [J].

Al-Amin, Zainab M. ;

Thomson, Martha ;

Al-Qattan, Khaled K. ;

Peltonen-Shalaby, Riitta ;

Ali, Muslim .

BRITISH JOURNAL OF NUTRITION, 2006, 96 (04) :660-666

[3] Physiological and Therapeutical Roles of Ginger and Turmeric on Endocrine Functions [J].

Al-Suhaimi, Ebtesam A. ;

Al-Riziza, Noorah A. ;

Al-Essa, Reham A. .

AMERICAN JOURNAL OF CHINESE MEDICINE, 2011, 39 (02) :215-231

[4]

[Anonymous], EGYPT ACAD J BIOL SC

[5]

[Anonymous], 2005, INDIAN J PHARM SCI

[6] Update on the Chemopreventive Effects of Ginger and its Phytochemicals [J].

Baliga, Manjeshwar Shrinath ;

Haniadka, Raghavendra ;

Pereira, Manisha Maria ;

D'Souza, Jason Jerome ;

Pallaty, Princy Louis ;

Bhat, Harshith P. ;

Popuri, Sandhya .

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2011, 51 (06) :499-523

[7] Determination of In vitro antidiabetic effects, antioxidant activities and phenol contents of some herbal teas [J].

Bueyuekbalci, Aynur ;

El, Sedef Nehir .

PLANT FOODS FOR HUMAN NUTRITION, 2008, 63 (01) :27-33

[8] Ginger and its Health Claims: Molecular Aspects [J].

Butt, Masood Sadiq ;

Sultan, M. Tauseef .

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2011, 51 (05) :383-393

[9]

Cárdenas-León M, 2009, REV INVEST CLIN, V61, P505

[10] The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives [J].

Chen, Lei ;

Magliano, Dianna J. ;

Zimmet, Paul Z. .

NATURE REVIEWS ENDOCRINOLOGY, 2012, 8 (04) :228-236

← 1 2 3 4 →