Pathological tau proteins in postencephalitic parkinsonism: Comparison with Alzheimer's disease and other neurodegenerative disorders

被引：45

作者：

BueeScherrer, V

Buee, L

Leveugle, B

Perl, DP

Vermersch, P

Hof, PR

Delacourte, A

机构：

[1] INSERM,U422,F-59045 LILLE,FRANCE

[2] HOP ROGER SALENGRO,DEPT NEUROL,LILLE,FRANCE

[3] CUNY MT SINAI SCH MED,FISHBERG RES CTR NEUROBIOL,NEW YORK,NY 10029

[4] CUNY MT SINAI SCH MED,NEUROBIOL AGING LABS,NEW YORK,NY 10029

[5] CUNY MT SINAI SCH MED,DEPT GERIATR & ADULT DEV,NEW YORK,NY 10029

[6] CUNY MT SINAI SCH MED,DEPT OPHTHALMOL,NEW YORK,NY 10029

[7] CUNY MT SINAI SCH MED,DEPT PATHOL NEUROPATHOL,NEW YORK,NY 10029

[8] UNIV ALBERTA,FAC PHARM & PHARMACEUT SCI,EDMONTON,AB T6G 2N8,CANADA

来源：

ANNALS OF NEUROLOGY | 1997年 / 42卷 / 03期

关键词：

D O I：

10.1002/ana.410420312

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Immunohistochemical and biochemical analyses of hyperphosphorylated tau proteins, the major component of neurofibrillary tangles, were performed in different brain regions From patients presenting with postencephalitic parkinsonism. Neurofibrillary tangles were found in hippocampus, neocortical areas (mostly in supragranular layers), and several subcortical structures. By immunoblotting, a tau protein triplet similar to the one seen in Alzheimer's disease was observed. This biochemical approach allows for the definition of postencephalitic parkinsonism from certain neurodegenerative disorders such as progressive supranuclear palsy and corticobasal degeneration.

引用

页码：356 / 359

页数：4

共 19 条

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