Rate of aneuploidy in miscarriages following in vitro fertilization and intracytoplasmic sperm injection

Objective: To evaluate the incidence of aneuploidy in miscarriages after IVF and intracytoplasmic sperm injection (ICSI) procedures. Design: Retrospective study. Setting: University IVF program. Patient(s): All IVF patients with missed abortions undergoing uterine curettage. Intervention(s): Cytogenetic analysis of products of conception (POC). Main Outcome Measure(s): Incidence of aneuploidy in POC. Result(s): Thirty-two of 59 specimens (54%) reviewed were abnormal. The patients with ICSI were more likely to have aneuploidy identified in their POC than conventional IVF, 76% vs. 41%. The average ages in these groups were similar: 37.1 vs. 37.8 years. There was a trend toward decreased aneuploidy with day 5 compared to day 3 embryo transfers; 38% vs. 63%. Conclusion(s): We found a significantly higher aneuploidy rate in the abortuses of patients who conceived with ICSI. It is possible that this increased incidence is due to abnormalities in the sperm of patients with ICSI, but could also be partially related to the technique itself. (Fertil Steril((R)) 2004;81:1270-2. (C)2004 by American Society for Reproductive Medicine.).