Economic evaluation of donepezil treatment for Alzheimer's disease in Japan

被引:33
作者
Ikeda, S [1 ]
Yamada, Y [1 ]
Ikegami, N [1 ]
机构
[1] Keio Univ, Sch Med, Dept Hlth Policy & Management, Shinjuku Ku, Tokyo 1608582, Japan
关键词
Alzheimer's disease; donepezil; economic evaluation; cost-utility analysis; quality-adjusted life years;
D O I
10.1159/000048631
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
To demonstrate the economic impact of donepezil treatment for patients with mild to moderate Alzheimer's disease (AD) in Japanese clinical settings, we conducted a cost-utility analysis using the Markov model. This analysis was made from a payer's perspective, and the cost was estimated based on the fee schedule of the Japanese national health insurance and the long-term care insurance. The results of the clinical trial of donepezil on AD in Japan were used to estimate the drug efficacy. Under the base-case analysis with a 2-year time horizon, donepezil treatment for patients with mild to moderate AD was considered to be an economically dominant strategy compared to conventional therapy. Copyright (C) 2002 S. Karger AG, Basel.
引用
收藏
页码:33 / 39
页数:7
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