Therapeutic Use of Infliximab in Tuberculosis to Control Severe Paradoxical Reaction of the Brain and Lymph Nodes

被引：133

作者：

Blackmore, Timothy K. ^{[1
]}

Manning, Laurens ^{[1
]}

Taylor, William J. ^{[2
]}

Wallis, Robert S. ^{[3
]}

机构：

[1] Capital & Coast Dist Hlth Board, Wellington, New Zealand

[2] Hutt Valley Dist Hlth Board, Wellington, New Zealand

[3] PPD, Washington, DC USA

来源：

CLINICAL INFECTIOUS DISEASES | 2008年 / 47卷 / 10期

关键词：

D O I：

10.1086/592695

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Paradoxical reactions are immune-mediated exacerbations of disease triggered by tuberculosis treatment. Paradoxical reactions involving the central nervous system may be life threatening. Infliximab (tumor necrosis factor antibody) profoundly inhibits cellular immune responses to Mycobacterium tuberculosis. We describe a case in which infliximab was used to control steroid-resistant tuberculosis paradoxical reaction involving the central nervous system.

引用

页码：E83 / E85

页数：3

共 12 条

[1] PARADOXICAL ENLARGEMENT OR DEVELOPMENT OF INTRACRANIAL TUBERCULOMAS DURING THERAPY - CASE-REPORT AND REVIEW [J].

AFGHANI, B ;

LIEBERMAN, JM .

CLINICAL INFECTIOUS DISEASES, 1994, 19 (06) :1092-1099

[2] Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients [J].

Bourgarit, A ;

Carcelain, G ;

Martinez, V ;

Lascoux, C ;

Delcey, V ;

Gicquel, B ;

Vicaut, E ;

Lagrange, PH ;

Sereni, D ;

Autran, B .

AIDS, 2006, 20 (02) :F1-F7

[3] Paradoxical reaction during tuberculosis treatment in HIV-seronegative patients [J].

Carvalho, ACC ;

De Iaco, G ;

Saleri, N ;

Pini, A ;

Capone, S ;

Manfrin, M ;

Matteelli, A .

CLINICAL INFECTIOUS DISEASES, 2006, 42 (06) :893-895

[4]

Hanauer Stephen B, 2004, Rev Gastroenterol Disord, V4 Suppl 3, pS18

[5] Immunoadjuvant prednisolone therapy for HIV-associated tuberculosis: A phase 2 clinical trial in Uganda [J].

Mayanja-Kizza, H ;

Jones-Lopez, E ;

Okwera, A ;

Wallis, RS ;

Ellner, JJ ;

Mugerwa, RD ;

Whalen, CC .

JOURNAL OF INFECTIOUS DISEASES, 2005, 191 (06) :856-865

[6] Neutralization of tumor necrosis factor (TNF) by antibody but not TNF receptor fusion molecule exacerbates chronic murine tuberculosis [J].

Plessner, Hillarie L. ;

Lin, P. Ling ;

Kohno, Tadahiko ;

Louie, James S. ;

Kirschner, Denise ;

Chan, John ;

Flynn, JoAnne L. .

JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (11) :1643-1650

[7] Adjunctive thalidomide therapy for childhood tuberculous meningitis: Results of a randomized study [J].

Schoeman, JF ;

Springer, P ;

van Rensburg, AJ ;

Swanevelder, S ;

Hanekom, WA ;

Haslett, PAJ ;

Kaplan, G .

JOURNAL OF CHILD NEUROLOGY, 2004, 19 (04) :250-257

[8] Intractable intracranial tuberculous infection responsive to thalidomide: Report of four cases [J].

Schoeman, Johan F. ;

Fieggen, Graham ;

Seller, Neil ;

Mendelson, Marc ;

Hartzenberg, Bennie .

JOURNAL OF CHILD NEUROLOGY, 2006, 21 (04) :301-308

[9]

Vidal CG, 2005, CLIN INFECT DIS, V40, P756, DOI 10.1086/427941

[10] Mathematical modeling of the tumor necrosis cause of tuberculosis during factor blockade [J].

Wallis, Robert S. .

ARTHRITIS AND RHEUMATISM, 2008, 58 (04) :947-952

← 1 2 →