pH sensitive interpenetrating network microgels of sodium alginate-acrylic acid for the controlled release of ibuprofen

被引:100
作者
Babu, VR [1 ]
Rao, KSVK [1 ]
Sairam, M [1 ]
Naidu, BVK [1 ]
Hosamani, KM [1 ]
Aminabhavi, TM [1 ]
机构
[1] Karnatak Univ, Ctr Excellence Polymer Sci, Drug Delivery Div, Dharwad 580003, Karnataka, India
关键词
sodium alginate; acrylic acid; IPNs; drug delivery;
D O I
10.1002/app.22760
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
pH-Sensitive interpenetrating network (IPN) microgels (MGs) of sodium alginate (NaAlg) and acrylic, acid have been prepared by using water-in-oil (W/O) emulsion technique. The MGs were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffractometer (X-RD). The release of ibuprofen (113), an anti-inflammatory drug, from these MGs was studied in pH 1.2 and 7.4 media. MG net-work consists of NaAlg, which disintegrates in the intestinal fluid, while poly(acrylic acid) provides pH-sensitivity to the microgel network. The system developed in this study showed a pH-sensitivity for the release of 113, which was attributed to the diffusion controlled release of the drug through the surfaces of MGs that undergo disintegration after swelling, depending upon the chemical composition of MGs and pH of the medium. (c) 2005 Wiley Periodicals, Inc.
引用
收藏
页码:2671 / 2678
页数:8
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