Measurement of nitric oxide in the rat cerebral cortex during hypercapnoea

被引：14

作者：

Harada, M

Fuse, A

Tanaka, Y

机构：

[1] Department of Anesthesiology, Kyoto Pref. University of Medicine, Kamigyoku, Kyoto 602, Kawaramachi-Hirokoji

来源：

NEUROREPORT | 1997年 / 8卷 / 04期

关键词：

cerebral blood flow; electrode; hypercapnoea; laser Doppler flowmetry; nitric oxide; 7-nitroindazole; (7-NI);

D O I：

10.1097/00001756-199703030-00036

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CHANGES in nitric oxide (NO) concentration and cerebral blood flow (CBF) in the parietal cortex during hypercapnoea were investigated in anaesthetized rats, using a NO-selective electrode and laser Doppler flowmetry. When hypercapnoea was induced by inhalation of 5% CO2 for 10 min, both the NO concentration and CBF increased. After administration of 7-nitroindazole, a neuronal NO synthase (nNOS) inhibitor, both the basal NO and CBF decreased, and responses to hypercapnoea were also significantly suppressed by 70.1% and 73.2%, respectively, compared with the control state. These results suggest that NO derived from nNOS is involved not only in maintaining resting cerebral circulation but also in regulating CBF response during hypercapnoea.

引用

页码：999 / 1002

页数：4

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