Studies on cancer chemoprevention by traditional folk medicines XXIV. Inhibitory effect of a coumarin derivative, 7-isopentenyloxycoumarin, against tumor-promotion

被引：30

作者：

Baba, M

Jin, YR

Mizuno, A

Suzuki, H

Okada, Y

Takasuka, N

Tokuda, H

Nishino, H

Okuyama, T

机构：

[1] Meiji Pharmaceut Univ, Dept Nat Med & Phytochem, Tokyo 2048588, Japan

[2] Natl Canc Ctr, Res Inst, Expt Pathol & Chemotherapy Div, Chuo Ku, Tokyo 1040045, Japan

[3] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2002年 / 25卷 / 02期

关键词：

Heracleum lanatum; anti-tumor promoting activity; ornithine decarboxylase (ODC); 7-isopentenyloxycoumarin;

D O I：

10.1248/bpb.25.244

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

7-Isopentenyloxycoumarin (1) was isolated from Heracleum lanatum MICHX. (Umbelliferae). Compound 1 inhibited phospholipid metabolism and Epstein-Barr virus activation caused by a potent tumor promoter. In an in vivo experiment, topical application of I suppressed skin-tumor-formation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene (DMBA) initiated mice. And it also suppressed ornithine decarboxylase activity stimulated by TPA on mouse skin. These results indicated that 7-isopentenyloxycoumarin is one of the effective compounds from natural resources for treating skin tumor formation.

引用

页码：244 / 246

页数：3

共 13 条

[1]

Baba M., 1999, Journal of Traditional Medicines, V16, P102

[2]

Baba M, 2000, BIOL PHARM BULL, V23, P660, DOI 10.1248/bpb.23.660

[3] ORNITHINE DECARBOXYLASE (EC4.1.1.17) ASSAY BASED UPON THE RETENTION OF PUTRESCINE BY A STRONG CATION-EXCHANGE PAPER [J].