Physical assignment of the bovine MHC class IIa and class IIb genes

被引：17

作者：

Hess, M

Goldammer, T

Gelhaus, A

Ried, K

Rappold, G

Eggen, A

Bishop, MD

Schwerin, M

Horstmann, RD

机构：

[1] Bernhard Nocht Inst Trop Med, Dept Mol Med, D-20359 Hamburg, Germany

[2] Res Inst Biol Farm Anim, Dept Biol Mol, Dummerstorf, Germany

[3] Univ Heidelberg, Inst Human Genet, Heidelberg, Germany

[4] INRA, CRJ, Lab Genet Biochim & Cytogenet, Jouy En Josas, France

[5] Amer Breeders Serv, DeForest, WI USA

来源：

CYTOGENETICS AND CELL GENETICS | 1999年 / 85卷 / 3-4期

关键词：

D O I：

10.1159/000015302

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Screening of a bovine yeast artificial chromosome (YAC) library revealed two clones which contain most of the class II genes of the major histocompatibility complex (MKC) known to date. The YACs were mapped by fluorescence in situ hybridization (FISH) and characterized for the class II genes they contain. We found that the classic class II genes BoLA- DQA, -DQB, -DRA, and -DRB3 are located at BTA 23q21 and the non-classic class II genes DYA DIB, LMP2, LMP7, TAP2, BoLA-DOB, -DMA, -DMB, and -DNA are located at BTA 23q12-->q13. These two different mapping locations confirm and extend previous findings of a gross physical distance between classic and non-classic MHC class II genes in cattle.

引用

页码：244 / 247

页数：4

共 22 条

[1] LINKAGE RELATIONSHIPS IN THE BOVINE MHC REGION - HIGH RECOMBINATION FREQUENCY BETWEEN CLASS-II SUBREGIONS [J].