Organobase-Catalyzed Amidation of Esters with Amino Alcohols

被引：50

作者：

Caldwell, Nicola ^{[1
]}

Jamieson, Craig ^{[1
]}

Simpson, Iain ^{[2
]}

Tuttle, Tell ^{[1
]}

机构：

[1] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland

[2] AstraZeneca, Oncol Innovat Med Unit, Macclesfield SK10 4TG, Cheshire, England

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 10期

基金：

英国工程与自然科学研究理事会;

关键词：

CARBOXYLIC-ACIDS; CONVENIENT; EFFICIENT; REAGENTS;

D O I：

10.1021/ol400987p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.

引用

页码：2506 / 2509

页数：4

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