Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes

被引：311

作者：

Cunha, Angelo B. M.

Frey, Benicio N.

Andreazza, Ana C.

Goi, Julia D.

Rosa, Adriane R.

Goncalves, Carlos A.

Santin, Aida

Kapczinski, Flavio

机构：

[1] Hosp Clin Porto Alegre, Ctr Pesquisas, Bipolar Disorders Program, BR-90035003 Porto Alegre, RS, Brazil

[2] Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Neuropsychiat, BR-97105900 Santa Maria, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Inst Ciencias Bas Saude, Dept Biochem, BR-90035003 Porto Alegre, RS, Brazil

来源：

NEUROSCIENCE LETTERS | 2006年 / 398卷 / 03期

关键词：

bipolar disorder; brain-derived neurotrophic factor; depression; mania; mood stabilizers; pathophysiology;

D O I：

10.1016/j.neulet.2005.12.085

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Genetic and pharmacological studies have suggested that brain-derived neurotrophic factor (BDNF) may be associated with the pathophysiology of bipolar disorder (BD). The present study investigated serum BDNF levels in manic, depressed, euthymic BD patients and in matched healthy controls, using an enzyme-linked immunosorbent assay (sandwich-ELISA). Serum BDNF levels were decreased in manic (p = 0.019) and depressed (p = 0.027) BD patients, as compared with euthymic patients and controls. Serum BDNF levels were negatively correlated with the severity of manic (r = -0.37, p = 0.005) and depressive (r = -0.30, p = 0.033) symptoms. These findings further support the hypothesis that the BDNF signaling system may play a role in the pathophysiology of BD. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：215 / 219

页数：5

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